Thermo Fisher Scientific APC10 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human APC10 protein. Validated for WB, IHC, and IP applications. Supplied as liquid, 1.5 mg/mL concentration. Suitable for research use in studying cell cycle regulation and mitosis control.
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- PA131765
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,500 |
| Immunohistochemistry (IHC) | 1:250–1:1,000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide GADPKQLERTG, corresponding to amino acids 10–20 of Human APC10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2226991 |
Product Specific Information
PA1-31765 detects APC10 from human samples.
Target Information
Cell cycle–regulated protein ubiquitination and degradation within subcellular domains are essential for normal mitotic progression.
APC10 is a conserved component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle–regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase.
APC/C degrades anaphase inhibitors, mitotic cyclins, and spindle-associated proteins to ensure proper sequence of mitotic events.
APC10 may regulate the binding of specific substrates to the APC/C complex, similar to coactivators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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