Thermo Fisher Scientific FANCD2 Recombinant Rabbit Monoclonal Antibody (SN73-08)
FANCD2 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현된 Protein A 정제 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN73-08 |
| Immunogen | Synthetic peptide within Human FANCD2 aa 191–240 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809598 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability and promotes accurate pairing of homologs during meiosis. It is involved in the repair of DNA double-stranded breaks via homologous recombination and single-stranded annealing. FANCD2 also stabilizes BLM at abnormal structures induced by replicative stress and promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene cause Fanconi anemia complementation group D2, which affects bone marrow elements, leading to anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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