Thermo Fisher Scientific IGF1R/CD221 Monoclonal Antibody (IGF1R/4667)
IGF1R/CD221 단백질을 표적으로 하는 마우스 단클론 항체로, 인간 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, PBS 버퍼에 보존제 없이 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1–4 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Neutralization (Neu) | Assay-dependent |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IGF1R/4667 |
| Immunogen | Recombinant fragment (around aa550–750) of human IGF1R protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IGF1R, also known as Insulin-like Growth Factor 1 (IGF-1) Receptor, is a receptor tyrosine kinase activated by IGF-1 and IGF-2. IGF1R has been implicated in a variety of cancers. The protein forms a tetramer consisting of two alpha and two beta subunits. The alpha-subunits bind to IGF-1 with higher affinity than IGF-2. Binding induces a conformational change, followed by autophosphorylation of IGF-1R at positions 1134, 1135, and 1136. The activated receptor phosphorylates substrate proteins, leading to sequential activation of RAS, RAF, and MAPK isoforms (ERK, p38, JNK), which drive gene transcription and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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