Thermo Fisher Scientific NF-kappaB1 Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

NF-kB is a nuclear transcription factor activated by various extracellular and intracellular stimuli such as cytokines, UV radiation, stress, injury, and bacterial or viral products. It regulates cellular events including cell growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-kB, belongs to the Rel protein family and is synthesized as a p105 precursor protein. It includes an N-terminal conserved RHD region containing nuclear localization signal, DNA-binding, and dimerization domains.
NFKB1 (p50) forms homodimers or heterodimers with p65, creating the functional NF-kB factor. It directs nuclear translocation and DNA-binding of NF-kB.
Pathological roles of NF-kB have been implicated in AIDS, hematogenic cancer cell metastasis, and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.