Thermo Fisher Scientific COX2 Polyclonal Antibody
COX2 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. 인간 및 마우스 반응성, 0.5 mg/mL 농도, TBS 버퍼에 BSA 포함. 연구용 전용 제품.
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- PA19032
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Thermo Fisher Scientific COX2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL | View 5 publications |
| Immunohistochemistry (IHC) | – | View 3 publications |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | View 2 publications |
| Flow Cytometry (Flow) | 10 µg/mL | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C terminus amino acids NPTVLLKERSTEL (aa 592–604) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2084941 |
Product Specific Information
- Predicted to react with bovine, canine, and porcine based on sequence homology.
- Tested in Peptide ELISA with antibody detection limit dilution up to 1:32,000.
Target Information
COX2 converts arachidonate to prostaglandin H2 (PGH2), a key step in prostanoid synthesis and inflammatory prostaglandin production.
This conversion involves two reactions:
- Cyclooxygenase (COX) reaction: arachidonate → prostaglandin G2 (PGG2)
- Peroxidase reaction: PGG2 → prostaglandin H2 (PGH2)
COX2 is constitutively expressed in tissues such as endothelium, kidney, and brain, and up-regulated under pathological conditions including cancer and inflammation.
It is linked to increased cell adhesion, phenotypic changes, resistance to apoptosis, and tumor angiogenesis.
In cancer cells, COX2 promotes prostaglandin E2 (PGE2) production, affecting motility, proliferation, and apoptosis resistance.
COX2 activity can be inhibited by calcitriol (active Vitamin D) and glucocorticoids, and is targeted by NSAIDs like aspirin to reduce inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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