Thermo Fisher Scientific DDB2 Polyclonal Antibody
Thermo Fisher Scientific의 DDB2 Polyclonal Antibody는 인간 DDB2 단백질을 인식하는 토끼 다클론 항체로, Western blot, IHC, ICC, Flow cytometry, IP 등에 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공되어 안정적 보관이 가능합니다.
- 카탈로그번호
- PA579143
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | – |
| Flow Cytometry (Flow) | 1–3 µg/1x10⁶ cells | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human DDB2 recombinant protein (Position: M1–T115) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746259 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, designated DDB1 and DDB2, respectively. The DDB heterodimer participates in the repair of DNA damaged by ultraviolet light. Also known as UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF), and hepatitis B virus X-associated protein 1 (XAP-1), DDB binds to damaged cyclobutane pyrimidine dimers (CPDs).
Mutations in the DDB2 gene are associated with xeroderma pigmentosum group E, an autosomal recessive disease characterized by hypersensitivity to sunlight, high incidence of skin cancer, and neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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