Thermo Fisher Scientific DDR2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

DDR2 is a member of a subclass of receptor tyrosine kinases (RTKs) containing a distinct extracellular region with a factor VIII-like domain. DDR1 and DDR2 are potently inhibited by Gleevec. DDR2 is required for normal bone development and regulates osteoblast differentiation and chondrocyte maturation via MAP kinase signaling leading to RUNX2 activation. It also regulates extracellular matrix remodeling by up-regulating collagenases MMP1, MMP2, and MMP13, facilitating cell migration and tumor invasion. DDR2 promotes fibroblast migration and proliferation, contributing to cutaneous wound healing.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.