Thermo Fisher Scientific KIF1C Polyclonal Antibody
인간 KIF1C 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 세포 내 소기관 및 수송 관련 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KIF1C. Recombinant protein control fragment (Product #RP-100039) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643095 |
Product Specific Information
- Immunogen sequence:
QAHICKLMGI LQQVKLQNSS KDWELQALQD RMVCMERIIP LAQDHEDENE EGGEFHWA - Antigen sequence identity:
- Mouse: 71%
- Rat: 72%
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins, responsible for the distribution of organelles, vesicles, and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis.
KIF1C belongs to the KIF1/Unc104 family of kinesin-like proteins, involved in the transport of mitochondria or synaptic vesicles in axons. Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein abundantly expressed in heart and skeletal muscle. Tyrosine phosphorylation may regulate KIF1C-mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C can form homodimers and noncovalently associate with 14-3-3 beta, gamma, epsilon, and zeta. In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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