Thermo Fisher Scientific TNNC1 Monoclonal Antibody (OTI8F8), TrueMAB
인간 TNNC1 단백질을 인식하는 단클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 연구용으로 근육 수축 조절 단백질 트로포닌 C 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8F8 |
| Immunogen | Full length human recombinant protein of human TNNC1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Troponin (Tn) is the central regulatory protein of striated muscle contraction.
Tn consists of three components:
- Tn-I: Inhibitor of actomyosin ATPase
- Tn-T: Contains the binding site for tropomyosin
- Tn-C: Binds calcium ions
The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
As calcium is taken up by troponin-C, the thin filament undergoes conformational changes enabling actin-myosin interaction, ATP hydrolysis, and tension generation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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