Thermo Fisher Scientific Phospho-NFkB p105 (Ser927) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of NF-κB p105/p50 only when phosphorylated at Serine 927.

Target Information

NF-κB is a nuclear transcription factor activated by various extracellular and intracellular stimuli such as cytokines, UV radiation, stress, injury, and microbial products. It regulates multiple cellular processes including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa subunit of NF-κB, is synthesized as a p105 precursor protein containing an N-terminal conserved RHD region with nuclear localization, DNA-binding, and dimerization domains. NFKB1 (p50) can form homodimers or heterodimers with p65 to generate functional NF-κB complexes. It plays a key role in nuclear translocation and DNA-binding of NF-κB.
Aberrant NF-κB activity has been implicated in AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.