Thermo Fisher Scientific NR3C1 Monoclonal Antibody (OTI7A11), TrueMAB

Applications

• Western Blot (WB): 1:2,000 dilution tested

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that functions as both a transcription factor and regulator of other transcription factors.
It is typically cytoplasmic until ligand binding induces nuclear transport.
Expression is observed in various heart tissues, including atria, ventricles, aorta, and septum.
Alternative splicing and promoter usage generate multiple transcript variants and isoforms.
Mutations in NR3C1 are associated with glucocorticoid resistance.
Activation requires chaperone protein complexes, and the receptor binds steroids such as dexamethasone with nanomolar affinity.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.