Thermo Fisher Scientific IL-23 p19 Polyclonal Antibody
IL-23 p19 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS buffer에 0.02% sodium azide 포함. Raji cell lysate를 양성 대조로 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the carboxy terminus of human IL-23 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152916 |
Product Specific Information
- Suggested positive control: Raji cell lysate
- PA5-20238 can be used with blocking peptide PEP-0357
Target Information
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. The p19 subunit, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rβ1 and an additional receptor subunit termed IL-23R, containing a STAT4 binding domain.
IL-23 is secreted by activated mouse and human dendritic cells. Its biological activities differ from IL-12, notably in T-cell activation and cytokine induction. Mouse IL-23 induces strong proliferation of memory T cells and production of IL-17, while human IL-23 promotes memory T cell proliferation and moderate IFN-γ production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-20238_IL-23_p19_Q9NPF7-1_Rabbit.svg, PA5-20238_IL-23_p19_Q9NPF7-1_Rabbit_PDP.jpeg)
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