
Thermo Fisher Scientific PNK1 Polyclonal Antibody
Rabbit 유래 다클론 항체로 인간 PNK1 단백질을 인식하며, Western blot, IHC, IP 등 다양한 응용에 적합. DNA 손상 복구 관련 연구에 활용 가능. 액상 형태로 제공되며, 4°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | |
| Immunohistochemistry (IHC) | 1:500–1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 100–150 of Human polynucleotide kinase 3-prime-phosphatase (PNK, UniProt ID: Q96T60-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Anti-human Polynucleotide Kinase (PNK) antibody recognizes a 57 kDa nuclear enzyme involved in DNA strand repair during replication, recombination, or in response to DNA damage.
PNK modifies DNA 5′-hydroxy and 3′-phosphate termini through phosphorylation and dephosphorylation, facilitating actions of DNA polymerase-β and DNA ligase III.
This enzyme plays a key role in maintaining genomic stability in human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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