Thermo Fisher Scientific PTPRK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

• Detects endogenous protein at a molecular weight of 65 kDa.
• Purity >95% by SDS-PAGE.

Target Information

Protein tyrosine phosphatases (PTPs) are type I transmembrane proteins, membrane-associated proteins, or nuclear-localized proteins. Examples include LAR, PTP alpha, PTP beta, PTP gamma, PTP delta, PTP epsilon, PTP zeta, PTPk, and PTP-mu.
Transmembrane PTPs play diverse roles during development and in adult tissues.

• LAR regulates insulin receptor phosphorylation.
• PTP alpha activity increases twofold upon phorbol ester stimulation, involving PKC-mediated serine phosphorylation.
• Overexpression of v-H-ras and Neu induces PTP epsilon expression in mammary tumors.
• Alternative splicing of PTP zeta produces phosphacan, a nervous tissue-specific proteoglycan.
• PTPk and PTP-mu share a conserved MAM domain enabling homophilic binding.
• PTP-mu localizes at cell contact points and may regulate cadherin/catenin complex assembly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.