Thermo Fisher Scientific MUC4 Monoclonal Antibody (1G8)
MUC4 단백질을 인식하는 Mouse monoclonal 항체로, Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트에 반응하며 Protein A로 정제된 액상 형태. 암 및 점막 관련 질환 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 3 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 7 publications |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 3 publications |
| Flow Cytometry (Flow) | – | View 2 publications |
| ELISA | Assay-dependent | View 2 publications |
| Miscellaneous PubMed (Misc) | – | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Bovine, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G8 |
| Immunogen | Rat ASGP-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533206 |
Target Information
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and plays a key role in protection and lubrication of epithelial surfaces. Abnormal MUC4 expression is observed in various carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been proposed as a potential biomarker for cancer detection.
MUC4 is also implicated in certain population-specific conditions, such as Taiwanese infertility, endometriosis, and gallstone formation in Chinese men. Given its critical role in mucosal surface protection, MUC4 dysfunction is associated with metastatic cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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