Thermo Fisher Scientific PUF60 Polyclonal Antibody
Thermo Fisher Scientific의 PUF60 Polyclonal Antibody는 인간 PUF60 단백질의 C-말단 펩타이드(aa 510-559)에 특이적으로 결합하는 토끼 유래 IgG 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 고순도 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human PUF60 (aa 510–559) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576685 |
Product Specific Information
- Peptide sequence: EIIVKIFVEF SIASETHKAI QALNGRWFAG RKVVAEVYDQ ERFDNSDLSA
- Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rat: 100%
Zebrafish: 100%
Target Information
PUF60 encodes a Ro RNP-binding protein that interacts with Ro RNPs, potentially conferring a gain of function. It forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein, repressing c-myc reporter activity via FUSE. PUF60 also targets transcription factor IIH, inhibiting activated transcription, and is implicated in xeroderma pigmentosum disorder. Two alternatively spliced transcript variants encode different isoforms, with evidence of multiple polyadenylation sites.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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