Thermo Fisher Scientific Bcl-2 Monoclonal Antibody (Bcl-2/100), eBioscience
Bcl-2 단백질을 표적으로 하는 마우스 단클론 항체로, 인간 시료에 반응합니다. Western blot, IHC, ELISA, Flow cytometry 등 다양한 응용에 적합합니다. 항체는 액상 형태이며 PBS 완충액에 보존되고, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Bcl-2 Monoclonal Antibody (Bcl-2/100), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 1 publication |
| Immunohistochemistry (IHC) | Assay-Dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Flow Cytometry | Assay-Dependent | View 1 publication |
| ELISA | Assay-Dependent | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Bcl-2/100 |
| Immunogen | Recombinant Human Bcl-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2–7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10597451 |
Additional Formats Available:
Product Specific Information
Bcl-2 is a key regulator of apoptosis and the founding member of the Bcl-2 family of apoptosis regulatory proteins. Its anti-apoptotic functions are achieved through modulation of the inner mitochondrial permeability transition pore, which regulates matrix Ca²⁺, pH, and voltage.
Applications Tested: ELISA, Flow Cytometry, Immunohistochemistry, Western Blotting.
Target Information
BCL-2 regulates apoptosis by either inhibiting or promoting cell death. Members of the BCL-2 family can form dimers to modulate apoptosis. For instance, Bag1 forms a heterodimer with BCL-2, enhancing its anti-apoptotic effect. Bax and Bak promote cytochrome c release from mitochondria, initiating apoptosis. Constitutive BCL-2 expression, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma. In follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, while normal centers are negative. Two transcript variants of BCL-2 differ in their C-terminal ends, and overexpression has been linked to cancers such as B-cell lymphoma and prostate cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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