Thermo Fisher Scientific KLDC3 Polyclonal Antibody
Human KLDC3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 사용 가능. Affinity Chromatography로 정제되었으며, PBS와 50% glycerol buffer에 보관. 세포질 내 KLHDC3 단백질 검출에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–382 of human KLHDC3 (NP_476502.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.17 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805547 |
Product Specific Information
Immunogen sequence:
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN AVSLRWTKLP PVKSAIRGQA PVVPYMRYGH STVLIDDTVL LWGGRNDTEG ACNVLYAFDV NTHKWFTPRV SGTVPGARDG HSACVLGKIM YIFGGYEQQA DCFSNDIHKL DTSTMTWTLI CTKGSPARWR DFHSATMLGS HMYVFGGRAD RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP PTPVLPEGRR SHSAFGYNGE LYIFGGYNAR LNRHFHDLWK FNPVSFTWKK IEPKGKGPCP RRRQCCCIVG DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYN LDQSCLPHDI RWELNAMTTN SNISRPIVSS HG
Positive Samples: H460, DU145, HepG2
Cellular Location: Cytoplasm
Target Information
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins with BTB domains are involved in transcriptional regulation via chromatin structure control.
The Kelch domain-containing protein 3 (KLHDC3), also designated PEAS, contains 5 Kelch repeats and may play a role in meiotic recombination. The gene encoding KLHDC3 maps to chromosome 6, which includes approximately 1,200 genes within 170 million base pairs. Deletion of part of the q arm of chromosome 6 is linked to early-onset intestinal cancer, suggesting a cancer susceptibility locus. Other diseases associated with genes on chromosome 6 include Porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome, 21-hydroxylase deficiency, and maple syrup urine disease. KLHDC3 protein is mainly expressed in the cytoplasm and is also found in meiotic chromatin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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