Thermo Fisher Scientific TGM2 Monoclonal Antibody (CUB 7402)
Transglutaminase II(TGM2)을 인식하는 Mouse Monoclonal Antibody(CUB 7402)로 WB, IHC(P), IP 등 다양한 응용에 적합. Dog, Guinea pig, Human, Rabbit 시료에 반응하며 Protein G 정제 및 PBS/BSA buffer로 제공. 연구용 전용 제품.
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Thermo Fisher Scientific TGM2 Monoclonal Antibody (CUB 7402)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | 45 publications |
| Immunohistochemistry (IHC) | – | 24 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL | – |
| Immunohistochemistry (Frozen) (IHC (F)) | – | 1 publication |
| Immunocytochemistry (ICC/IF) | – | 11 publications |
| Flow Cytometry (Flow) | – | 1 publication |
| ELISA | – | 3 publications |
| Immunoprecipitation (IP) | 2 µg/mL | 6 publications |
| Neutralization (Neu) | – | 1 publication |
| Dot blot (DB) | – | 1 publication |
| Miscellaneous PubMed (Misc) | – | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Guinea pig, Human, Rabbit |
| Published Species | Chicken, Dog, Hamster, Human, Mouse, Non-human primate, Pig, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CUB 7402 |
| Immunogen | Purified guinea pig liver TGase II |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985077 |
Product Specific Information
MA5-12739 targets Transglutaminase II in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Guinea Pig, Human, and Rabbit samples.
The immunogen is purified guinea pig liver TGase II.
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for activity. In mammals, eight distinct TGase isoenzymes have been identified.
Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer’s disease, elevated tTGase activity leads to polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, forming neurofibrillary tangles.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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