Thermo Fisher Scientific PDI Recombinant Rabbit Monoclonal Antibody (23GB2890)

Applications and Tested Dilution

Product Specifications

Target Information

Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds.
At the cell surface, it acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially causing structural modifications of exofacial proteins.
Inside the cell, PDI facilitates the formation and rearrangement of disulfide bonds in nascent proteins. At high concentrations, it functions as a chaperone inhibiting aggregation of misfolded proteins, while at low concentrations, it facilitates aggregation (anti-chaperone activity).
PDI may cooperate with other chaperones in structural modification of the TG precursor in hormone biogenesis and serves as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
It also acts as a receptor for LGALS9, retaining P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the redox state, and enhancing cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.