Thermo Fisher Scientific CD56 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 500-720 of human NCAM1 (NP_8519962) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD56 (NCAM),uniProtId:P13591-2,ncbiNodeId:9606,antigenRange:500-720,antigenLength:858,antigenImageFileName:PA5-88353_CD56_NCAM_P13591-2_Rabbit.svg,antigenImageFileNamePDP:PA5-88353_CD56_NCAM_P13591-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804851

Product Specific Information

Immunogen sequence: LEFILVQADT PSSPSIDQVE PYSSTAQVQF DEPEATGGVP ILKYKAEWRA VGEEVWHSKW YDAKEASMEG IVTIVGLKPE TTYAVRLAAL NGKGLGEISA ASEFKTQPVQ GEPSAPKLEG QMGEDGNSIK VNLIKQDDGG SPIRHYLVRY RALSSEWKPE IRLPSGSDHV MLKSLDWNAE YEVYVVAENQ QGKSKAAHFV FRTSAQPTAI PANGSPTSGL S; Positive Samples: HT-1080, SW480, 293T, LO2, Mouse brain; Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor, Single-pass type I membrane protein

Target Information

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa. CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. Polysialic modification results in reduction of CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma. Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.