Thermo Fisher Scientific CD56 Polyclonal Antibody
CD56 (NCAM) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 및 생쥐 반응성, Western blot 및 ELISA에 적합. 고순도 Affinity Chromatography 정제, 안정적인 PBS/glycerol 저장용액 구성. 연구용으로만 사용 가능.
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Thermo Fisher Scientific CD56 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 500–720 of human NCAM1 (NP_8519962) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.38 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804851 |
Product Specific Information
Immunogen sequence:
LEFILVQADT PSSPSIDQVE PYSSTAQVQF DEPEATGGVP ILKYKAEWRA VGEEVWHSKW YDAKEASMEG IVTIVGLKPE TTYAVRLAAL NGKGLGEISA ASEFKTQPVQ GEPSAPKLEG QMGEDGNSIK VNLIKQDDGG SPIRHYLVRY RALSSEWKPE IRLPSGSDHV MLKSLDWNAE YEVYVVAENQ QGKSKAAHFV FRTSAQPTAI PANGSPTSGL S
Positive Samples: HT-1080, SW480, 293T, LO2, Mouse brain
Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor, Single-pass type I membrane protein
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is found on T cells and NK cells and is involved in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. It is a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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