Thermo Fisher Scientific IgA Secretory Component/ECM1 Monoclonal Antibody (SC05)
인체 및 랫트 반응성의 ECM1 단백질을 인식하는 단클론 항체로, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합합니다. Protein A/G 정제 및 200 µg/mL 농도로 제공되며, 4°C 보관 권장. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SC05 |
| Immunogen | Full-length native protein (purified) corresponding to Human IgA Secretory Component. Affinity-purified secretory component from human colostrum. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ECM1 (Extracellular Matrix Protein 1) plays a significant role in regulating extracellular matrix organization and cell adhesion. It is expressed in various tissues including the skin, lung, and liver, and is involved in the development and progression of several diseases such as cancer and dermatological disorders. ECM1 interacts with extracellular matrix proteins like collagen and fibronectin, influencing cell proliferation, migration, and invasion. It also contributes to endochondral bone formation, angiogenesis, and tumor biology. Mutations in ECM1 are associated with lipoid proteinosis (Urbach-Wiethe disease), characterized by thickening of skin and mucosae. Multiple isoforms exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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