Thermo Fisher Scientific TLK1 Polyclonal Antibody
Western blot 및 Immunoprecipitation에 적합한 TLK1 폴리클로날 항체. Rabbit IgG 기반의 비결합(Unconjugated) 항체로, 인간 TLK1 단백질의 716-766 잔기 영역을 면역원으로 사용. 4°C 보관, 1년 권장 유효기간.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 716 and 766 of Human tousled-like kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TLK1 (Tousled-like kinase 1) is a nuclear serine/threonine kinase potentially involved in the regulation of chromatin assembly. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR), and this inactivation is mediated by the S-phase DNA damage checkpoint. Suppression of TLK1 activity after DNA double-strand breaks, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS, and CHK1. The Tousled-like kinases, first described in Arabidopsis, play a role in chromatin assembly regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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