Thermo Fisher Scientific SHOX Polyclonal Antibody
SHOX 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 ICC/IF에서 0.25–2 µg/mL로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, 장기 보관 시 -20°C에서 보관 권장.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SHOX. Recombinant protein control fragment (Product #RP-105897) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662067 |
Product Specific Information
Immunogen sequence:
AFVSKSFDQKS KDGNGGGGGG GGKKDSITYR EVLESGLARS RELGTSDSSL QDITEGGGHC PVHLFKDHVD NDKEKLKEFG TARVAEGIYE C
Highest antigen sequence identity to the following orthologs:
- Mouse: 31%
- Rat: 24%
Target Information
Homeodomain proteins (HP) are transcriptional regulators that coordinate the expression of genes involved in development, differentiation, and cellular transformation. HPs are characterized by a conserved domain of 60 amino acid residues that recognize and bind regulatory regions of target genes.
SHOX, a member of the bicoid subfamily of the paired homeobox family, controls fundamental aspects of growth and development and undergoes splicing resulting in two isoforms, SHOXA and SHOXB.
- SHOXA: Expressed in skeletal muscle, placental, pancreas, heart, and bone marrow fibroblast; lower expression in kidney and lung.
- SHOXB: Highly expressed in osteogenic cells; not expressed in brain, kidney, liver, or lung.
Defects in the SHOX gene cause Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia (LMD).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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