Thermo Fisher Scientific Transgelin 2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rat

Target Information

Transgelin (also designated SM22alpha) is abundantly expressed in smooth muscle cells. Transgelin-2 (SM22alpha homolog) is a homolog of transgelin, also expressed in smooth muscle cells and peritoneal B-1 cells.
The human transgelin-2 gene (TAGLN2), located on chromosome 1q23.1–q25, encodes a 199 amino acid protein containing a calponin-like repeat and a calponin-homology (CH) domain.
Transgelin-2 may function similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac, and skeletal muscle, but later restricted to vascular and visceral smooth muscle cells and low levels in heart tissue.
Transgelin downregulation in transformed cell lines may indicate early transformation onset. Transgelin binds actin, causing actin fibers to gel rapidly, with a binding ratio of 1:6 actin monomers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.