Thermo Fisher Scientific MSRA Polyclonal Antibody
MSRA 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며, 세포 내 산화 손상 방어 연구에 활용됩니다. Affinity 정제 방식으로 제조되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 24–235 of human MSRA (NP_036463.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.21 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804997 |
Product Specific Information
Immunogen sequence:
GNSASNIVSP QEALPGRKEQ TPVAAKHHVN GNRTVEPFPE GTQMAVFGMG CFWGAERKFW VLKGVYSTQV GFAGGYTSNP TYKEVCSEKT GHAEVVRVVY QPEHMSFEEL LKVFWENHDP TQGMRQGNDH GTQYRSAIYP TSAKQMEAAL SSKENYQKVL SEHGFGPITT DIREGQTFYY AEDYHQQYLS KNPNGYCGLG GTGVSCPVGI KK
Positive Samples: Mouse kidney, Rat kidney
Cellular Location: Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus
Target Information
Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA depends on bound metal and cofactors, requiring reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. Substrates of MsrA include calmodulin, HIV protease, and α1-proteinase-inhibitor. Recent studies suggest a link between MsrA and Alzheimer’s disease in mammals.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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