Thermo Fisher Scientific Cyclophilin B Recombinant Rabbit Monoclonal Antibody (ST05-22)
Cyclophilin B 단백질을 인식하는 recombinant rabbit monoclonal 항체로, Western blot과 IHC(P) 등에 사용 가능. 높은 특이성과 일관된 로트 간 재현성을 제공하며, 동물 유래 성분이 없는 포뮬레이션으로 연구용에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST05-22 |
| Immunogen | Synthetic peptide within Human Cyclophilin B (aa 171–215) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809459 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Clones are screened to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Immunophilins are a family of soluble cytosolic receptors that bind to immunosuppressant agents such as cyclosporin A (CsA) or FK506.
- Proteins binding FK506 are termed FKBP (FK506 Binding Proteins).
- Proteins binding CsA are called cyclophilins (CyP).
Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium- and calmodulin-dependent protein phosphatase involved in T-cell activation, explaining the immunosuppressive effects of CsA and FK506.
Immunophilins act as peptidyl prolyl cis-trans-isomerases (PPIase), catalyzing protein folding and rearrangement steps, which are inhibited by their respective immunosuppressants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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