Thermo Fisher Scientific CD31/PECAM-1 Monoclonal Antibody (PECAM1, 3528)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling via dual immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases. CD31 is ubiquitously expressed within the vascular compartment, mainly at junctions between adjacent cells.
The N-terminal Ig-like domain mediates homophilic binding, essential for cell-cell interactions. CD31 plays key roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis.
It is one of the key regulatory molecules in the vascular system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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