Thermo Fisher Scientific CD180 Polyclonal Antibody
CD180 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. Human 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS 기반 완충액에 1% BSA, 20% glycerol 포함. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 198–429 of Human RP105 (CD180) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546410 |
Product Specific Information
- Recommended positive control: Jurkat cells
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
CD180 (also known as RP105, Bgp95, LY64) is a type I membrane glycoprotein of the Toll-like receptor (TLR) family. Unlike other TLRs, CD180 lacks the TIR domain in its cytoplasmic tail. Its expression depends on coexpression with MD-1 and parallels that of TLR4 on antigen-presenting cells. CD180 modulates LPS recognition and B cell signaling by interacting with the TLR4 complex, inhibiting ligand binding. Engagement of CD180 by monoclonal antibodies triggers B cell activation, upregulation of CD80/CD86, and cell enlargement. The extracellular domain contains leucine-rich repeats (LRR) forming the RP105/MD-1 receptor complex. CD180 dysfunction is linked to Kawasaki Disease and may contribute to rheumatic disease pathology.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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