Thermo Fisher Scientific Phospho-Progesterone Receptor (Ser400) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Progesterone Receptor only when phosphorylated at Serine 400.

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two isoforms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), generated by alternative translation initiation sites.
PR-B is the transcriptionally active form responsible for activating genes related to endometrial maintenance, pregnancy, and inhibition of ovulation.
PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon binding progesterone, conformational change allows receptor dimerization and binding to progesterone response elements (PRE), initiating transcription.
A null mutation in the PGR gene results in reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.