Thermo Fisher Scientific alpha-2b Adrenergic Receptor Polyclonal Antibody
Rabbit polyclonal antibody targeting human alpha-2b adrenergic receptor. Validated for IHC (paraffin) with 1:200–1:500 dilution. Purified via antigen affinity chromatography and supplied as liquid form in PBS with glycerol. For research use only.
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- PA564258
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- pk
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Applications
Tested Application and Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human alpha-2b Adrenergic Receptor. Recombinant protein control fragment (Product #RP-103896). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637884 |
Product Specific Information
Immunogen sequence:
IAKRSNRRGP RAKGGPGQGE SKQPRPDHGG ALASAKLPAL ASVASAREVN
Sequence identity (orthologs):
- Mouse: 57%
- Rat: 55%
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor (GPCR) superfamily, including three subtypes: alpha2A, alpha2B, and alpha2C. These receptors regulate neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system.
The alpha2B subtype associates with eIF-2B, a guanine nucleotide exchange protein involved in translation regulation. A polymorphic variant lacking three glutamic acids shows decreased receptor phosphorylation and desensitization, potentially contributing to reduced basal metabolic rate and obesity pathogenesis.
The alpha2B adrenergic receptor gene contains no introns in its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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