Thermo Fisher Scientific alpha-2b Adrenergic Receptor Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human alpha-2b Adrenergic Receptor. Recombinant protein control fragment (Product #RP-103896). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:alpha-2b Adrenergic Receptor,uniProtId:P18089-1,ncbiNodeId:9606,antigenRange:198-247,antigenLength:450,antigenImageFileName:PA5-64258_alpha-2b_Adrenergic_Receptor_P18089-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64258_alpha-2b_Adrenergic_Receptor_P18089-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637884

Product Specific Information

Immunogen sequence: IAKRSNRRGP RAKGGPGQGE SKQPRPDHGG ALASAKLPAL ASVASAREVN

Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 55%.

Target Information

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.