Thermo Fisher Scientific OX40L Polyclonal Antibody
Human OX40L 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Flow Cytometry에 사용 가능. KLH 결합 합성 펩타이드 면역원으로 제작되었으며, Protein A 및 항원 친화 크로마토그래피로 정제됨. PBS 용액에 보관되며 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 97–125 amino acids from the central region of human TNFSF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.9 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542052 |
Target Information
The tumor necrosis factor superfamily member TNFSF4 (OX40L) is a type II membrane-bound, non-covalently linked homotrimeric protein. It is expressed on antigen-presenting cells such as dendritic cells and activated B cells, as well as on vascular endothelial cells, mast cells, and natural killer cells.
TNFSF4 signals specifically through the TNFRSF4 receptor, which is predominantly expressed on CD4⁺ T cells and certain activated CD8⁺ T cells. The TNFRSF4/TNFSF4 interaction provides a costimulatory signal essential for productive communication between antigen-presenting cells and target T cells. This signaling enhances cell proliferation and survival, and upregulates expression of RANTES, IL-2, IL-3, and IFN-γ. TNFRSF4/TNFSF4 signaling plays a critical role in immunotolerance.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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