Thermo Fisher Scientific NR0B2 Polyclonal Antibody
Human NR0B2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. KLH 결합 합성 펩타이드(aa 56–83)를 면역원으로 사용하며, 고순도 정제 및 안정적 저장이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 56–83 amino acids from the central region of human NR0B2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542051 |
Target Information
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain.
It belongs to the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, some of which are orphan nuclear receptors without known ligands.
The NR0B2 protein interacts with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation.
It also interacts with estrogen receptors, leading to inhibition of their function.
Studies suggest that NR0B2 represses nuclear hormone receptor-mediated transactivation through two mechanisms: competition with coactivators and direct transcriptional repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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