Thermo Fisher Scientific BCL2A1 Polyclonal Antibody
Human BCL2A1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, Flow Cytometry에 사용 가능. 2 mg/mL 농도의 액상 형태이며, 장기 보관 시 -20°C에서 보관 권장. 세포 생존 및 항아폽토시스 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 53–81 amino acids from the central region of human BCL2A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2542061 |
Target Information
Bcl-2 related Protein A1 is a member of the BCL-2 protein family. These proteins form hetero- or homodimers and act as anti- and pro-apoptotic regulators involved in various cellular activities such as embryonic development, homeostasis, and tumorigenesis.
The protein encoded by this gene reduces the release of pro-apoptotic cytochrome c from mitochondria and blocks caspase activation. It is a direct transcription target of NF-kappa B in response to inflammatory mediators and is up-regulated by extracellular signals such as GM-CSF, CD40, phorbol ester, TNF, and IL-1. This suggests a cytoprotective function essential for lymphocyte activation and cell survival.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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