Thermo Fisher Scientific KAT13C/NCOA2 Polyclonal Antibody, Biotin
KAT13C/NCOA2 단백질을 인식하는 Thermo Fisher Scientific의 Biotin 결합 폴리클로날 항체입니다. Western blot, ELISA, IP 등 다양한 응용에 적합하며, Human, Mouse, Rat 반응성을 보입니다. 고순도 Affinity chromatography 정제, 안정적 액상 형태로 연구용에 최적화되어 있습니다.
- 카탈로그번호
- NUCR2-BIOTIN
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific KAT13C/NCOA2 Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid 1375–1425 on rat NuCR2/GRIP-1/SRC-2 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2) or TIF2, aids in the function of nuclear hormone receptors.
These receptors act as conditional transcription factors that regulate gene expression related to cell growth, development, and homeostasis.
Members of the nuclear hormone receptor superfamily include steroid and class II nuclear receptors, which have three domains:
- N-terminal transcriptional activation domain
- Central DNA-binding domain
- C-terminal hormone-binding domain
Prior to hormone binding, steroid receptors remain inactive in complexes with heat-shock protein-90 and other stress proteins.
Hormone binding induces conformational changes, leading to dissociation from inhibitory complexes, homodimer formation, and DNA enhancer binding, thereby modulating gene transcription.
Transcriptional coactivator proteins such as SRC2 are essential for initiating transcription after enhancer binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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