Thermo Fisher Scientific KAT13C/NCOA2 Polyclonal Antibody, Biotin

Thermo Fisher Scientific KAT13C/NCOA2 Polyclonal Antibody, Biotin

Applications and Tested Dilution

Product Specifications

Target Information

SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2) or TIF2, aids in the function of nuclear hormone receptors.
These receptors act as conditional transcription factors that regulate gene expression related to cell growth, development, and homeostasis.
Members of the nuclear hormone receptor superfamily include steroid and class II nuclear receptors, which have three domains:

• N-terminal transcriptional activation domain
• Central DNA-binding domain
• C-terminal hormone-binding domain

Prior to hormone binding, steroid receptors remain inactive in complexes with heat-shock protein-90 and other stress proteins.
Hormone binding induces conformational changes, leading to dissociation from inhibitory complexes, homodimer formation, and DNA enhancer binding, thereby modulating gene transcription.
Transcriptional coactivator proteins such as SRC2 are essential for initiating transcription after enhancer binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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