Thermo Fisher Scientific KAT13C/NCOA2 Polyclonal Antibody, FITC
FITC로 표지된 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트 SRC2/NCOA2 단백질 검출에 적합합니다. Western blot, ELISA, IP 등에 사용 가능하며, 형광 특성은 498/517 nm입니다. 고순도 친화 크로마토그래피 정제 및 안정한 보관용 완충액 포함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid 1375–1425 on rat NuCR2/GRIP-1/SRC-2 protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2) or TIF2, aids in the function of nuclear hormone receptors. These receptors act as conditional transcription factors regulating gene expression involved in cell growth, development, and homeostasis. Members of this receptor superfamily are structurally characterized by three domains:
- N-terminal transcriptional activation domain
- Central DNA-binding domain
- C-terminal hormone-binding domain
Before hormone binding, steroid receptors remain inactive in a complex with heat-shock proteins. Hormone binding induces conformational changes, causing dissociation from inhibitory complexes and enabling receptor dimerization, DNA binding, and transcriptional activation. Coactivator proteins such as SRC2 are required for efficient transcription initiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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