Thermo Fisher Scientific Nurr1 Polyclonal Antibody, Biotin
Nurr1 단백질을 인식하는 Biotin 결합 Rabbit Polyclonal 항체로, 인간 및 마우스 시료에 반응. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 고순도 Affinity chromatography 정제, 안정적인 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acid region 566–591. The peptide was post-synthetically modified for high antigenicity before coupling to carrier protein using hetero bifunctional cross linker. Sequence: CTQGLQRIFYLKLEDLVPPPAIIDKL |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans. NURR1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene are associated with dopaminergic dysfunction-related disorders such as Parkinson’s disease, schizophrenia, and manic depression. Misregulation may also be linked to rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, and additional alternate splice variants may exist but are not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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