Thermo Fisher Scientific MMP9 Monoclonal Antibody (4A3)
인간 MMP9 단백질을 인식하는 Thermo Fisher Scientific의 4A3 단클론 항체로, WB 및 IHC에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용되며, 염증 반응 및 종양 연구에 유용합니다.
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Thermo Fisher Scientific MMP9 Monoclonal Antibody (4A3)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A3 |
| Immunogen | Synthetic peptide derived from the N-terminus of the human MMP-9 protein and mouse myeloma Ag 8563 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076954 |
Product Specific Information
A suggested positive control for this product is esophageal adenocarcinoma.
Target Information
MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase belonging to a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins.
MMP9 is secreted as a 92 kDa zymogen, and cleavage of pro-MMP9 results in an active enzyme of 82 kDa. It contains:
- Gelatin-binding domain with three fibronectin type II units
- Catalytic domain with a zinc-binding site
- Proline-rich type V collagen-homologous domain
- Hemopexin-like domain
MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, and endothelial cells. It plays roles in:
- Inflammatory responses
- Tissue remodeling and wound healing
- Tumor growth and metastasis
MMP9 contributes to skin carcinogenesis and degrades type IV and V collagens. Studies suggest involvement in IL-8-induced mobilization of hematopoietic progenitor cells and tumor-associated tissue remodeling. Elevated MMP9 levels are associated with idiopathic atrial fibrillation progression and aortic aneurysm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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