Thermo Fisher Scientific TMEM24 Polyclonal Antibody
TMEM24 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료 반응성, ICC/IF 검증 완료. Affinity chromatography로 정제된 액상 항체로, PI(4,5)P2 신호 조절 연구에 적합. 연구용 전용 제품.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 534–621. Recombinant protein control fragment. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091736 |
Product Specific Information
- Immunogen sequence:
LIISGVSKVP IAQDELALSL GYAASLEASV QDDAGTSGGP SSPPSDPPAM SPGPLDALSS PTSVQEADET TRSDISERPS VDDIESET - Antigen sequence identity: Mouse 94%; Rat 93%
Target Information
Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843).
It maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843).
Plays a key role in coordination of Ca²⁺ and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, tethering the two bilayers (PubMed:28209843).
In response to elevated cytosolic Ca²⁺, it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the membrane (PubMed:28209843).
Positively regulates insulin secretion in response to glucose by replenishing PI(4,5)P2 pools and enabling calcium channel opening (PubMed:28209843).
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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