Thermo Fisher Scientific TMEM24 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  LIISGVSKVP IAQDELALSL GYAASLEASV QDDAGTSGGP SSPPSDPPAM SPGPLDALSS PTSVQEADET TRSDISERPS VDDIESET
• Antigen sequence identity: Mouse 94%; Rat 93%

Target Information

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843).
It maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843).
Plays a key role in coordination of Ca²⁺ and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, tethering the two bilayers (PubMed:28209843).
In response to elevated cytosolic Ca²⁺, it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the membrane (PubMed:28209843).
Positively regulates insulin secretion in response to glucose by replenishing PI(4,5)P2 pools and enabling calcium channel opening (PubMed:28209843).
[UniProt]

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.