Thermo Fisher Scientific CCDC134 Polyclonal Antibody
CCDC134 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. ICC/IF 실험에 적합하며, 고순도의 액상 형태로 제공됩니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 170–202). Recombinant protein control fragment (Product #RP-110232). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091919 |
Product Specific Information
- Immunogen sequence: GISEKDSNFQ NPFKIDRTEF IPSTDPFQKA LRE
- Antigen sequence identity: Mouse 85%; Rat 91%
Target Information
The coiled-coil domain is a common protein motif involved in protein oligomerization, found in proteins such as transcription factors and intermediate filaments.
CCDC134 is a secretory protein that inhibits the transcriptional activity of Elk1. Overexpression of CCDC134 suppresses phosphorylation of Erk and JNK/SAPK but not p38 MAPK. Conversely, siRNA-mediated knockdown of CCDC134 activates Elk1 transcriptional activity and phosphorylation of Erk and JNK/SAPK, indicating a potential inhibitory role of CCDC134 in MAPK-mediated Elk1 transcription.
CCDC134 is widely expressed in normal adult tissues, tumors, and cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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