Thermo Fisher Scientific ATF2 Monoclonal Antibody (PCRP-ATF2-1B4)
ATF2 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot, ICC/IF, Flow cytometry, IP 등 다양한 응용에 사용 가능. 인간 반응성, Mouse IgG2b 형식이며 핵 내 ATF2 검출에 적합. 24개월 안정성 보유, 연구용으로만 사용.
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Thermo Fisher Scientific ATF2 Monoclonal Antibody (PCRP-ATF2-1B4)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Immunoprecipitation (IP) | 1–2 µg/100–500 µg lysate |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-ATF2-1B4 |
| Immunogen | Recombinant full-length human ATF2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: HeLa or U87 cells
- Cellular Localization: Nucleus
Specificity Comments:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein performs mechanistically distinct functions, binding to the cAMP-responsive element (CRE), forming homodimers or heterodimers with c-Jun, and stimulating CRE-dependent transcription.
It also acts as a histone acetyltransferase (HAT) that acetylates histones H2B and H4 in vitro, representing sequence-specific factors that activate transcription through chromatin modification.
Additionally, ATF2 may participate in the DNA damage response independently of its transcriptional role. Several alternatively spliced transcript variants are known.
Predicted to react in mouse and rat.
Target Information
ATF-2 (also known as CRE-BP1) is a transcription factor that binds AP-1 and CRE DNA response elements and belongs to the ATF/CREB family of leucine zipper proteins. It interacts with viral oncoproteins and tumor suppressors, serving as a target for SAPK/JNK and p38 MAPK signaling pathways.
ATF-2 activity is stimulated by cellular stress such as genotoxic agents, inflammatory cytokines, and UV irradiation. Stress induces phosphorylation at Thr69 and Thr71 by SAPK and p38 MAPK, activating ATF-2 transcriptional function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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