Thermo Fisher Scientific TMEM59 Polyclonal Antibody
TMEM59 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC에 적합합니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 냉장 보관 가능하며 장기 보관 시 -20°C에서 안정적입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near amino terminus of human TMEM59 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153831 |
Product Specific Information
- Suggested positive control: human kidney tissue lysate
- PA5-21065 can be used with blocking peptide PEP-1179.
Target Information
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis.
TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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