Thermo Fisher Scientific EFCAB4B Polyclonal Antibody
EFCAB4B 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 2-8°C 보관 권장. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide near the carboxy terminus of human EFCAB4B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152066 |
Product Specific Information
- A suggested positive control is mouse kidney tissue lysate.
- PA5-21060 can be used with blocking peptide PEP-1174.
Target Information
CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation.
CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration.
Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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