Thermo Fisher Scientific Progesterone Receptor Polyclonal Antibody
Rabbit polyclonal antibody against human progesterone receptor. Validated for Western blot at 1:1,000 dilution. Recognizes residues surrounding Tyr541. Suitable for research use only. Supplied as liquid, affinity purified, stored at -20°C.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Tyr541 of human progesterone receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 67 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984406 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other PR family members.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with pregnancy establishment and maintenance.
PR exists as two forms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), produced via alternative translation initiation sites.
PR-B is transcriptionally active, regulating genes involved in endometrial maintenance, pregnancy, and ovulation inhibition.
PR-A differs from PR-B by a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
Inactive PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene can lead to reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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