Thermo Fisher Scientific Desmin Polyclonal Antibody
Desmin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 적합. 인간, 마우스, 랫트 시료에서 반응. 항원 친화 크로마토그래피로 정제된 액상 제품이며, -20°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: Not specified
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mammal |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of human desmin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 7 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic), Wet ice (international) |
| RRID | AB_10980171 |
Product Specific Information
- It is not recommended to aliquot this antibody.
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly expressed in all types of muscle cells (cardiac, skeletal, and smooth muscle). Its expression is stage and tissue-specific, induced during terminal skeletal muscle cell differentiation.
In skeletal and cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk. In smooth muscle, the expression pattern is more heterogeneous.
Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, such as rhabdomyosarcomas and leiomyosarcomas. Changes in desmin distribution have been noted during myocardial dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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