Thermo Fisher Scientific Phospho-Estrogen Receptor alpha (Ser118) Recombinant Rabbit Monoclonal Antibody (ARC1549)
Recombinant rabbit monoclonal antibody recognizing phospho-Estrogen Receptor alpha (Ser118). Validated for WB and ELISA. High specificity and sensitivity. Supplied in liquid form with 1.5 mg/mL concentration. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1549 |
| Immunogen | A synthetic phosphorylated peptide around S118 of human Estrogen Receptor alpha (ESR1) (P03372) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849755 |
Product Specific Information
- Immunogen sequence: QLSPF
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor that, upon estrogen binding, undergoes conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This interaction regulates gene transcription through coactivator or corepressor recruitment.
There are two main forms, ERα (ESR1) and ERβ (ESR2), encoded by separate genes. Alternative RNA splicing generates multiple ERα isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa).
Estrogen receptors are broadly expressed across tissues, essential for sexual development and reproductive function, and implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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