Thermo Fisher Scientific Human ACE2 (aa18-740), His-tag Recombinant Protein
인간 ACE2 단백질(aa18-740, His-tag)로, HEK293 세포에서 발현된 고순도 재조합 단백질입니다. ELISA, Western blot 등 다양한 분석에 사용 가능하며, SARS-CoV 수용체 연구에 적합합니다. PBS(pH 7.4) 용액 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
Control (Ctrl)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | HEK293 cells |
| Amino Acid Sequence | Human ACE2, amino acids 18–740 with a C-terminal His-tag |
| Tag | His-tag |
| Class | Recombinant |
| Type | Protein |
| Purity | >95% by reducing SDS-PAGE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Human ACE2 (Gln18–Ser740) is produced by a mammalian expression system.
Purity is >95% by SDS-PAGE.
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology.
In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis.
Recently, ACE2 has also been shown to be a functional receptor of the SARS coronavirus.
The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII.
While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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