Thermo Fisher Scientific GNAS Polyclonal Antibody
인간, 생쥐, 랫트에 반응하는 Rabbit IgG 폴리클로날 항체로, GNAS 단백질을 타깃으로 합니다. Western blot에 1:500~1:2,000 희석 비율로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS와 글리세롤 버퍼에 보관되며 연구용으로 적합합니다.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human GNAS (UniProt ID: O95467-1, antigen range: 1–245) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720406 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity >95% by SDS-PAGE.
Target Information
Mutations in the GNAS gene are associated with:
- Pseudohypoparathyroidism types 1a and 1b
- Albright hereditary osteodystrophy
- McCune-Albright syndrome
- Progressive osseous heteroplasia
- Polyostotic fibrous dysplasia of bone
- Some pituitary tumors
The GNAS gene exhibits complex imprinted expression patterns, encoding maternally, paternally, and biallelically expressed proteins derived from alternatively spliced transcripts. These transcripts involve differentially methylated regions and unique promoter structures. Mutations may result in atypical autosomal dominant inheritance requiring maternal transmission for full penetrance.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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