Thermo Fisher Scientific VASP Monoclonal Antibody (OTI1H8), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Vasodilator-stimulated phosphoprotein (VASP) belongs to the Ena-VASP protein family.
Members of this family contain:

• EHV1 N-terminal domain: binds proteins with E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions
• Proline-rich domain: binds SH3 and WW domain-containing proteins
• C-terminal EVH2 domain: mediates tetramerization and binds G and F actin

VASP is involved in filamentous actin formation, cell adhesion, motility, and intracellular signaling pathways regulating integrin–extracellular matrix interactions.
It is regulated by cyclic nucleotide-dependent kinases PKA and PKG.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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