Thermo Fisher Scientific SHH Polyclonal Antibody
SHH 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 높은 순도(>95%)와 항원 친화 정제 방식으로 제조. 인간 및 랫트 반응성, 연구용으로 적합.
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Thermo Fisher Scientific SHH Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide of human SHH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803778 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Sonic Hedgehog (SHH) is expressed only during embryogenesis and plays a key role in patterning the early embryo. It is crucial for ventral neural tube formation, anterior-posterior limb axis development, and ventral somite patterning. The SHH protein is produced as a precursor that undergoes autocatalytic cleavage. The N-terminal fragment is soluble and responsible for signaling activity, while the C-terminal fragment aids in precursor processing and attaches a cholesterol moiety to the N-terminal product. This modification restricts the N-terminal product to the cell surface, preventing diffusion throughout the embryo. Defects in SHH or its signaling pathway can lead to holoprosencephaly (HPE) and may be associated with VACTERL syndrome.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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